A: In general the answer to this is a clear NO.
However, to be completely honest, there are some conditions in which it is possible that the adjustment may be somewhat uncomfortable. If, for example, you are in acute pain, and spasm, then any motion of the affected area may be unpleasant.
And, sometimes it does happen that a patient who has underlying joint disease complicating the condition, may feel slightly worse before feeling better. But, for the vast majority of patients, the adjustment is simply a "relief".
Actually, in our experience the small minority of people who say they had a bad experience with a Chiropractor, are probably those whose Doctors failed to properly inform them of this possibility in advance of their treatment. So they just thought that the adjustment had a bad effect when they experienced what would have been a temporary increase in discomfort. Had they come right back to the Doctor, s/he would have adjusted them again, and most likely helped them past this initial, but for them, normal stage.